Abstract
Atrial fibrillation (AF) is the most common cardiac arrhythmias causing morbidity and mortality. Current treatment of AF is unsatisfactory as the mechanisms underlying the genesis and control of AF are not yet understood. Given the complexity of cardiac nonlinear dynamics, it is a grand challenge to underpin such mechanisms by classic bio-medical research. Recent advances in bio-systems engineering and sciences that uses multidisciplinary approaches shed light to study the functions of the heart. In this talk, I shall review recent progresses in the development of virtual physiological heart (e-Heart) and demonstrate its great potentials to investigate the functional impacts of some gene mutations in genesis of AF.