Abstract
This paper mainly introduces the cyber infrastructure and e-Science application practices of Chinese Academy of Sciences. We present current situation of the cyber infrastructure from research network infrastructure, high performance computing environment, scientific data infrastructure, collaboration environment and digital library. We briefly introduce e-Science application demonstrations supported by Chinese Academy of Sciences in the Eleventh 5-Year (2006-2011) period. Our understanding is that e-Science is the way leading to modernization of science and technology.